Symbol
Name
ID

Ets1
E26 avian leukemia oncogene 1, 5' domain
MGI:95455

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Autoimmunity
Disease(s) Associated with ETS1	Autoimmunity
type 1 diabetes mellitus

Mouse Phenotypes

immune system phenotype

increased B cell apoptosis

decreased thymocyte apoptosis

increased splenocyte apoptosis

decreased B cell proliferation

decreased T cell proliferation

abnormal thymus morphology

abnormal thymus subcapsular epithelium morphology

abnormal thymus cortex morphology

increased thymus weight

enlarged thymus

thymus hypoplasia

decreased thymocyte number

abnormal lymphopoiesis

abnormal B cell differentiation

decreased pro-B cell number

increased pro-B cell number

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-negative T cell number

increased double-positive T cell number

decreased mature B cell number

absent B-1a cells

increased plasma cell number

decreased B cell number

decreased NK cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased memory T cell number

decreased T cell number

decreased leukocyte cell number

abnormal CD8-positive, alpha beta T cell morphology

abnormal spleen morphology

abnormal spleen red pulp morphology

decreased spleen weight

small spleen

abnormal leukocyte physiology

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal T cell activation

Availability

Mouse Genotype

Ets1^m1Anu/Ets1^m1Anu

Ets1^tm1.1Dds/Ets1^tm1.1Dds

Ets1^tm1Fwa/Ets1^tm1Fwa

Ets1^tm1Jml/Ets1^tm1Jml

Ets1^tm2Jml/Ets1^tm2Jml

Ets1^tm1.1Dds/Ets1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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